Influence of Chelating Agents on the Distribution of Cobalt-60 in Albino Rats

Journal Article · Sat Mar 24 04:00:00 EST 1962 · Nature (London)

DOI:https://doi.org/10.1038/1931195a0· OSTI ID:4797244

SIVARAMAKRISHNAN, V. M.; SREENIVASAN, N. G.; SEKHARA VARMA, T. N.; BRAHMANANDAM, S.

Sixteen chelating agents, of which five form insoluble complexes (1- nitroso 2-naphthol, sodium diethyldithiocarbamate, oxine, rubeanic acid, and salicylaldehyde) were used. Male albino rats, weighing 200 to 300 g, received intravenously 0.5 ml of carrier-free Co/sup 60/ solution (about 16 mu ) and either 0.5 ml of isotonic saline (the controls) or 0.5 ml 5 mM solution of one of the chelating agents at pH about 7.0. After 24 hr the rats were killed, and the radioactivity in various organs, in a weighed specimen of blood, and in the urine and feces collected separately was determined. Most of the chelating agents tested caused profound changes in the distribution of the isotope. Many of the chelating agents caused decreased excretion (for example, only 17% with 1-nitroso 2-naphthol) and preferential localization in various organs. Among the prominent changes were localization of the isotope in the reticuloendothelial system (for example, liver and spleen) by rubeanic acid and BAL, in the lungs by oxine, in the carcass (muscles, bones, and skin) by 1-nitroso 2-naphthol, and slightly in the intestinal contents by sodium diethyldithiocarbamate, which largely increased the fecal excretion from 5 to 35%. An attempt to explain the varied effects of these and other chelating agents is given. (P.C.H.)

• Research Organization: Cancer Inst., Madras
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-012873
• OSTI ID: 4797244
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4821 Vol. 193; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDITY
BIOLOGY AND MEDICINE
BLOOD
BONES
CHELATES
COBALT 60
INTESTINE
LIVER
LUNGS
MEASURED VALUES
MUSCLES
RADIOACTIVITY
RATS
SKIN
SOLUTIONS
SPLEEN
TISSUES
URINE