THE PATH OF COBALT-60, IONIC OR CHELATED, IN ALBINO RATS AFTER INTRAVENOUS ADMINISTRATION

Journal Article · Wed Aug 01 04:00:00 EDT 1962 · Proc. Soc. Exptl. Biol. Med.

DOI:https://doi.org/10.3181/00379727-110-27661· OSTI ID:4778891

Sivaramakrishnan, V M; Sekhara Varma, T N; Brahmanandam, S; Nagarajan, B

The path of cobalt-60, administered alone as cobaltous chloride or with any one of the chelating agents 1-nitroso 2-naphthol, SDDC, rubeanic acid, BAL, EDTA, or cysteine, is traced by studying the tissue distribution at various times after intravenous administration to albino rats. With ionic cobalt and with a number of chelates, an initial accumulation of radioactivity in the liver is noted, even though subsequent distribution varies widely. The 1-nitroso 2naphthol chelate follows the route Blood yields Liver yields Skin, Bones and Muscles yields Excretion. EDTA- and cysteinechelates exhibit a marked apathy for the liver, but preferentially concentrate in the skin and bones. Quantitatively, the liver, skin, bones, and muscles are the chief tissues of physiological importance in cobalt metabolism. (auth)

• Research Organization: Cancer Inst., Madras
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-031459
• OSTI ID: 4778891
• Journal Information: Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 110
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMIDES
BAL
BIOLOGY AND MEDICINE
BLOOD
BONES
CHELATES
COBALT 60
COBALT CHLORIDES
CYSTEINE
EDTA
IONS
LIVER
METABOLISM
MUSCLES
ORGANIC ACIDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIOACTIVITY
RATS
SKIN
TRACER TECHNIQUES