NEW REAGENT FOR LABELING ORGANIC COMPOUNDS WITH TRITIUM

Journal Article · Tue Mar 20 04:00:00 EST 1962 · Journal of the American Chemical Society (U.S.)

DOI:https://doi.org/10.1021/ja00865a054· OSTI ID:4796918

Yavorsky, P M; Gorin, E

An evaluation was made of the powerful acid complex TH/sub 2/PO/sub 4/ - BF/sub 3/ for promoting hydrogen isotope exchange labeling. The complex is easily made by stoichiometric admixture of tritiated water and P/sub 2/O/sub 5/ and saturation with BF/sub 3/ gas. Advantages of this labeling method are: radiochemi-cally pure tracers often are produced immediately, obvi-ating drastic post-labeling purification that may be required for some acids. Labeling is very rapid, sometimes requiring only a few hours to complete. It is simple, requiring no special equipment as for gas handling or high temperatures, and very high specific activity tracers can be produced where desired by starting with highly tritiated water. Initial labeling results with 9 organic compounds are tabulated. (P.C.H.)

• Research Organization: Consolidation Coal Co., Library, Penna.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-013102
• OSTI ID: 4796918
• Journal Information: Journal of the American Chemical Society (U.S.), Journal Name: Journal of the American Chemical Society (U.S.) Vol. Vol: 84; ISSN JACSA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BORON FLUORIDES
CHEMISTRY
COMPLEXES
GASES
HIGH TEMPERATURE
HYDROGEN
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
PHOSPHORIC ACID
PHOSPHORUS OXIDES
RADIOCHEMISTRY
TABLES
TRACE AMOUNTS
TRITIUM
WATER