THE EFFECT OF THERAPY ON CELLS IN THE BLOOD OF LEUKEMIC PATIENTS CAPABLE OF INCORPORATING H$sup 3$ THYMIDINE
Technical Report
·
OSTI ID:4796205
The ability of circulating leukocytes to synthesize DNA was followed serially after therapy in patients with blood dyscrasias, using tritiated thymidine and autoradiography. Following Myleran therapy in myelocyte leukemia, the fall in labeled cells paralleled that of the total leukocyte count. In chronic lymphocytic leukemia, x-ray therapy to the spleen resulted in a marked drop in the total leukocyte court and a relative increase in the number of labeled cells. Steorid therapy did not decrease the leukocyte count or the number of labeled cells. The results indicate that these agents do not have a selective effect on circulating cells capable of DNA synthesis. The serial labeling indexes appear to be of little additional value for prognosis. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-16-028697
- OSTI ID:
- 4796205
- Report Number(s):
- BNL-5216
- Country of Publication:
- United States
- Language:
- English
Similar Records
Proliferative Potentials of Bone Marrow and Blood Cells Studied by in vitro Uptake of H3-Thymidine
THE EFFECTS OF RADIATION ON TOTAL AND DNA SYNTHESIZING CELLS OF THE BONE MARROW AND BLOOD
MYELOBLAST TURNOVER IN NORMAL AND LEUKEMIC STATES
Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Acta Haematologica
·
OSTI ID:4234760
THE EFFECTS OF RADIATION ON TOTAL AND DNA SYNTHESIZING CELLS OF THE BONE MARROW AND BLOOD
Technical Report
·
Sun Dec 31 23:00:00 EST 1961
·
OSTI ID:4740870
MYELOBLAST TURNOVER IN NORMAL AND LEUKEMIC STATES
Technical Report
·
Mon Oct 01 00:00:00 EDT 1962
·
OSTI ID:4636922