EARLY UPTAKE AND DOSIMETRY OF Zn$sup 65$ IN SHEEP

Journal Article · Wed Aug 01 04:00:00 EDT 1962 · Health Physics (England)

DOI:https://doi.org/10.1097/00004032-196208000-00010· OSTI ID:4796058

McKenney, J R; McClellan, R O; Bustad, L K

The uptake and distribution of Zn/sup 65/ were measured in three rams serially sacrificed at 5, 10, or 20 days following single administration; in two rams 20 days after single oral administration; and in three ewes in advanced pregnancy (with their fetuses) and in one ram fed Zn/sup 65/ daily for 2 weeks. Direct measurements with Victoreen pocket dosimeters were taken in the major tissues following sacri fice of one of the ewes and the ram fed Zn/sup 65/ daily. Data on the rams indicated that between 10 and 20% ingested radiozinc was absorbed from the gastrointestinal tract. Turnover rates of radiozinc were estimated at between 10 and 30% for most tissues and less than 2% per day for voluntary muscle and bone. In the ewes and ram fed Zn/sup 65/ for 2 weeks, the highest concentrations were found in the liver, kidney cortex, mammary tissue, pancreas, and spleen, respectively. There was a 3-day lag before appreciable uptake was observed in the blood cells. The fetuses contained concentrations from one-tenth to one-half those in comparable tissues of the ewes. Total body was observed to be the critical organ for the ram and ewe used for the doserate measurements. (auth)

• Research Organization: General Electric Co., Richland, Wash.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-028712
• OSTI ID: 4796058
• Report Number(s): HW-SA-2338; 0017-9078
• Journal Information: Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 8; ISSN HLTPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
ANIMALS
BIOLOGY AND MEDICINE
BONES
DOSEMETERS
FETUSES
GLANDS
INTESTINE
KIDNEYS
LIVER
MAMMARY GLANDS
METABOLISM
MUSCLES
PANCREAS
PREGNANCY
QUANTITY RATIO
SEX
SHEEP
SPLEEN
STOMACH
TISSUES
ZINC 65