DIFFERENCES IN THE REJECTION OF SKIN TRANSPLANTS AND BLOOD CELLS OF BONE MARROW DONOR ORIGIN BY RADIATION INDUCED CHIMERAS

Technical Report · Fri Mar 16 04:00:00 EST 1962

OSTI ID:4795645

Silverman, M S; Chin, P H

(C57L x A)F/sub 1/ mice which had survived lethal doses of x radiation when injected with rat bone marrow are frequently found to have rat circulating blood cells. These cells often persist for the remainder of the animal's life. In addition the mouse/rat chimeras will also accept donor rat skin grafts. The acceptance or rejection of the skin grafts is often used to determine the immunological tolerant state of the chimera. However, the data described in this report indicate that the circulating blood cells may persist in about 50% of these mice although rejection of the skin grafts occurs. Some of these partially tolerant mice are capable of producing antibodies against sheep red blood cells, but not against rat blood cells of either donor or allelogeneic orgin. Mice which have reverted to a completely non-tolerant state reject both the rat skin grafts and rat circulating blood cells, and form antibodies against the donor red blood cells. Three possible explanations for partial tolerance are offered, none of which are mutually exclusive. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-16-016178
• OSTI ID: 4795645
• Report Number(s): USNRDL-TR-553
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
ANTIBODIES
BIOLOGY AND MEDICINE
BLOOD CELLS
BONE MARROW
ERYTHROCYTES
IMMUNITY
LETHAL DOSE
LIFETIME
MICE
SHEEP
SKIN
TRANSPLANTS
X RADIATION