Influence of Pre- and Post-X-Irradiation Zymosan Administration on Reticuloendothelial Function
Phagocytic activity, evaluated by the intravascular removal rate of colloidal carbon, was determined in mice injected with the reticuloendothelial (RE) stimulating agent, trypsinized zymosan, either prior to or immediately after exposure to 1000 r. Half-times (t/2), global phagocytic activity, corrected phagocytic activity, and weight changes of liver and spleen were determined at frequent postirradiation intervals. The hyperphagocytic state induced by the injection of zymosan was unaltered after radiation exposure. Phagocytic function was significantly impaired in normal mice 96 hours after exposure. In contrast, the injection of zymosan after exposure maintained normal RE function but did not induce a hyperfunctional state. Survival to various doses of x irradiation was unaltered by zymosaninduced RE stimulation.
- Research Organization:
- Univ. of Tennessee, Memphis
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-016226
- OSTI ID:
- 4792329
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 4 Vol. 16; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
INFLUENCE OF RETICULOENDOTHELIAL HYPERFUNCTION ON BONE MARROW TRANSPLANTATION
Reduction of X-Ray Lethality in Mice by Agents Affecting the Reticuloendothelial System
Effects of long-term combination chemotherapy on the reticuloendothelial system
Journal Article
·
Sat Sep 01 00:00:00 EDT 1962
· American Journal of Physiology (U.S.)
·
OSTI ID:4771325
Reduction of X-Ray Lethality in Mice by Agents Affecting the Reticuloendothelial System
Journal Article
·
Thu Nov 30 23:00:00 EST 1961
· Radiation Research
·
OSTI ID:4805900
Effects of long-term combination chemotherapy on the reticuloendothelial system
Journal Article
·
Tue May 15 00:00:00 EDT 1984
· Cancer (Philadelphia); (United States)
·
OSTI ID:6975198