STUDIES IN THE METABOLISM OF CARRIER-FREE RADIORUTHENIUM. III. THE BEHAVIOUR OF NITROSYL-RUTHENIUM IN THE GASTROINTESTINAL TRACT

Journal Article · Wed Aug 01 04:00:00 EDT 1962 · Health Physics (England)

DOI:https://doi.org/10.1097/00004032-196208000-00008· OSTI ID:4792230

Bruce, R S; Carr, T E.F.; Collins, M E

A study was made of factors which affect the absorption of the nitrosyl complex of Ru/sup 106/ from the gastrointestinal tract of the rat. Absorption is normally complete within 2 hr. The rate of transit of the ruthenium through the gut and chemical combination with the contents may account for this limited period of absorption. However, about 20% of a dose is absorbed into the wall of the small intestine during the first hour while the total uptake into the rest of the body is only 2 to 4%. It appears, therefore, that passage from the gut wall into the blood is the limiting stage in the absorption of ruthenium nitrosyl. Fasting rats before the administration of ruthenium influences this stage and the 24-hr absorption into the body is increased threefold. The retention of ruthenium in the wall of the small intestine gives rise to considerable concentrations in the wall of the duodenum and upper jejunum. These tissues, which are particularly sensitive to radiation, consequently receive a higher total radiation dose than that resulting from the passage of the contents alone. (auth)

• Research Organization: Medical Research Council, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-028711
• OSTI ID: 4792230
• Journal Information: Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 8; ISSN HLTPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
BIOLOGY AND MEDICINE
BLOOD
INTESTINE
METABOLISM
QUANTITY RATIO
RADIOSENSITIVITY
RATS
RUTHENIUM 106
RUTHENIUM COMPLEXES
STOMACH
TISSUES