ACTION OF X RAYS ON ANTIBODY FORMATION FOLLOWING AN INJECTION OF A SINGLE ANTIGEN

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · Ann. Inst. Pasteur

OSTI ID:4789268

Loiseleur, J; Petit, M

Rabbits were irradiated with 100 to 900 r at various intervals (1 to 48 hr) before or after intravenous injection of ovalbumin, and serum antibody titers were determined 4 days after the injection. A dose of 600 r given 5 to 8 hr before antigen completely prevented the appearance of detectable antibody levels, whereas the same dose 16 to 24 hr before antigen allowed some antibody to be formed but to lower levels than in nonirradiated controls. It is suggested that in the longer interval between irradiation and antigen injection some antibody- forming lymphocytes had regenerated. Low x-ray doses (100 and 200 r) administered 6 hr before antibody actually gave a higher antibody response than in nonirradiated controls, but higher doses (300 to 900 r) given at this time inhibited the response, it being nil after doses above 500 r. No antibody could be detected when 600 r was given 1 to 48 hr after antigen injection, but with 300 r a slight response was noted if it was given 48 hr after antigen. (H.H.D.)

• Research Organization: Institut Pasteur, Paris
• NSA Number: NSA-17-001256
• OSTI ID: 4789268
• Journal Information: Ann. Inst. Pasteur, Journal Name: Ann. Inst. Pasteur Vol. Vol: 103
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALBUMINS
ANTIGENS
BIOLOGY AND MEDICINE
IMMUNITY
LYMPHOCYTES
METABOLISM
OVALBUMIN
PRODUCTION
RABBITS
RADIATION DOSES
RADIATION EFFECTS
REGENERATION
X RADIATION