The Relative Biological Effectiveness of 22-Mevp X-Rays, Cobalt-60 Gamma Rays, and 200-Kvcp X-Rays: V. Absorbed Dose to the Bone Marrow in the Rat and the Mouse
Calculations were made of the distribution of dose at the surface of semi-infinite tissue-tissue and bone-tissue layers for spectra of 200-kvcp x rays (0.5 mm Cu + 1 mm Ai, HVL 1.4 mm Cu), Co60 gamma rays, and 22-Mewp x rays. These calculations were applied to physical models of bone marrow cavities in the mouse and the rat, and the results were weighted for the gross distribution of active marrow in the animal. The distribution of functioning marrow across a cavity was assumed to be uniform. It was found that for both animals the bone marrow dose is greater than the soft-tissue dose in all three cases. The relative doses for the rat are 1.07 for 200-kvcp x rays, 1.01 for Co60 gamma rays, and 1.01 for 22-Mewp x rays. The relative doses for the mouse are 1.09, 1.01, and l.01, respectively. This suggests that, if mammalian RBE values are based on bone marrow dose, for both Fe59 uptake and lethality in the rat the RBE for Co60 vs 200-kvcp should be multiplied by 1.06, for 22-Mevp vs 200-kvcp the RBE should be multiplied by 1.06, and for 22-Mevp versus Co60 the RBE should be multiplied by 1.00. For the mouse, the RBE values should be multiplied by 1.08, 1.08, and 1.00, respectively.
- Research Organization:
- Univ. of Texas, M.D. Anderson Hospital and Tumor Inst., Houston
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-017517
- OSTI ID:
- 4789017
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 16; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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