CONTRIBUTION TO THE STUDY OF THE PROBLEM OF THE VARIABILITY OF TUBERCLE BACILLI

Journal Article · Fri Jun 01 04:00:00 EDT 1962 · Arch. Roumaines Pathol. Exptl. Microbiol.

OSTI ID:4784819

Gaiginski, A; Roman, I; Stavri, N; Timosca, S

Development of nonvirulent, alcohol-acid resi stant strains of tubercle bacilli under various chemical and physical stimuli was studied. One such attenuated strain was obtained by treatment of a virulent strain with trichloroiodopyridine at a concentration of 1% for 30 to 80 days. This strain conferred immunity in guinea pigs, except when the immunizing injections were given in mineral oil, a property also found wtth BCG. Ten attenuated strains were obtained from 5 virulent strains by ultraviolet or x irradiation. X irradiation was applied to 5- to 9-day cultures in doses of 1000 to 1500 r, and incubation was carried out for 30 days. Such irradiation did not modify BCG and Vallee bovine strains, nor did it alter the streptomycin, ioniazid, or paminosalicylate resistance of resistant virulent strains. (H.H.D.)

• Research Organization: Acad. Rumania, Jassy
• NSA Number: NSA-17-000051
• OSTI ID: 4784819
• Journal Information: Arch. Roumaines Pathol. Exptl. Microbiol., Journal Name: Arch. Roumaines Pathol. Exptl. Microbiol. Vol. Vol: 21
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDS
ALCOHOLS
ANTIBIOTICS
BACTERIA
BIOLOGY AND MEDICINE
CHEMICALS
DRUGS
GENETICS
GUINEA PIGS
HETEROCYCLICS
IMMUNITY
ISONIAZID
MYCOBACTERIUM TUBERCULOSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PAS
PYRIDINES
RADIATION DOSES
SALICYLIC ACID
SENSITIVITY
STREPTOMYCIN
ULTRAVIOLET RADIATION
X RADIATION