THE USE OF ISOIMMUNE SERA FOR IDENTIFICATION OF HEMOPOIETIC CELLS FROM BLOOD-INJECTED RADIAION CHIMERAS

Journal Article · Tue May 01 04:00:00 EDT 1962 · Annals of the New York Academy of Sciences (U.S.)

OSTI ID:4780007

Goodman, J W

Use has been made of the antigenic differences among mice with respect to both erythrocytes and nucleated cells to identify hemopoietic cells of radiation chimeras. By employing isoimmune sera in agglutination and cytotoxic techniques, it has been shown that long-term leukemoid blood chimeras contain lymphocytes, erythrocytes, and nucleated bone marrow cells of the blood-donor type; blood from normal mice can repopulate lymphoid tissues of radiationbone marrow chimeras, and the blood-derived cells might take part in graft-versus-host immune reactions; and normal peripheral leukocytes from F/sub 1/ hybrid donors can reestablish lymphopoiesis, granulopoiesis, and erythropoiesis when injected into lethally irradiated parent strain mice. Cytotoxic typing of the nucleated hemopoietic cells shows that they are of donor origin. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-17-002837
• OSTI ID: 4780007
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 97; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIGENS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BLOOD SERUM
BONE MARROW
CHIMERAS
ERYTHROCYTES
IMMUNITY
IRRADIATION
LETHAL DOSE
LEUCOCYTES
LEUKEMIA
LYMPHOCYTES
MICE
RECOVERY
TRANSPLANTS