Radiosensitivity of cells of Chinese hamster in vitro in relation to the cell cycle
Journal Article
·
· Experimental Cell Research
Analyses of radiation damage to chromosomes were made with Chinese hamster cells grown in vitro. The cells were pulse-labelled with tritiated thymidine immediately before irradiation. Samples were taken every two hours postirradiation for either metaphase or anaphase study. It was found that the cells originally in the G2 phase were about three to four times more radiosensitive than those in the S phase. It was also found that breakages of the chromosomal type induced by, radiation only occurred among cells in the G1 phase, and were absent among cells in the S phase at the time of irradiation. This suggests that the subunits of each chromatid separate at the time the cell commences DNA synthesis.
- Research Organization:
- Univ. of Texas, Houston
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-001286
- OSTI ID:
- 4776486
- Journal Information:
- Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 3 Vol. 27; ISSN 0014-4827
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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