The effect of total-body irradiation on the oral tissues of the Syrian hamster

Journal Article · Fri Jun 01 04:00:00 EDT 1962 · Oral Surgery, Oral Medicine, Oral Pathology

DOI:https://doi.org/10.1016/0030-4220(62)90259-1· OSTI ID:4776276

Mayo, J.; Carranza, F. A.; Epper, C. E.; Cabrini, R. L.

Whole-body doses of 400 to 2000 r were given to 6- to 8week-old hamsters (Mesocricetus auratus) to study the gross and histologic lesions developing in the oral region. Hamsters irradiated with doses of 700 r or more underwent a rapid systemic deterioration, with severe diarrhea, dehydration, and loss of weight. Edema of the face and fauces and suppurating blepharitis, progressing in a few cases to large orbital abscesses, were frequently found, especially with the higher doses. A hemorrhagic exudation was frequentiy seen coming from the nasal fossae. Animals irradiated with 400 r did not show oral lesions. With 500 r and 800 r, occasional small, noncharacteristic lesions in the oral cavity, such as excoriations and wounds, were noted. With 700 r, oral lesions were found in 30% of the animals; with 900 r and higher doses, oral lesions appeared in all animals. Oral lesions consisted of yellowish gray areas, apparently necrotic, in the following localizatlons: (1) gingival tissue in the lingual aspect of the lower incisors, (2) palatal aspect of the upper incisors, and (3) palatal gingival of the upper molars. With higher doses, the lesions Were of greater severity and appeared in other areas of the oral cavity, especially the tongue. In the animals that survived the 30-day experimental period, the oral lesions healed, leaving such sequelae as marked gingival recessions and retractile scars with obliteration of the mucobuccal fold. Microscopic lesions in the upper molar area were characterized by a sudden interruption of the normal oral Mucous membrane, close to the periodontal region and its replacement by a necrotic area of variable size. Neither these necrotic areas nor the surrounding mucous membrane had any hemorrhagic foci. The pulp was vital in spite of the presence of large areas of necrosis in the neighboring alveolar bone. The irradiated animals fed hard and soft diets showed only slight differences. The number of lesions found in the latter group was slightly greater than that found in the former group, although they were more severe than those found in the hard-diet group. (H.H.D.) l309 A 1-pass computer program in FORTRAN is presented that produces least squares estimates and standard errors for the constants of the Multi-Hit curve. The mathematical expression for the curve is S = 1 - STA1 - exp(- kD)!/sup n/ where S is the proportional response to a dose D, and k and n are constants to be estimated. The program permits the choice of 3 weighting factors and accepts data entered as individual values or as means with associated weights.

• Research Organization: Comision Nacional de Energia Atomica, Buenos Aires
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-001308
• OSTI ID: 4776276
• Journal Information: Oral Surgery, Oral Medicine, Oral Pathology, Journal Name: Oral Surgery, Oral Medicine, Oral Pathology Journal Issue: 6 Vol. 15; ISSN 0030-4220
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANIMALS
BIOLOGY AND MEDICINE
BODY
BONES
DIARRHEA
DIET
DISEASES
EDEMA
EYES
FOOD
HAMSTERS
HEMORRHAGE
INFECTIONS
INTESTINE
MICROSCOPY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
STOMACH
TISSUES
TONGUE
WEIGHT