TRANSPLANTABILITY OF AN X-RAY-INDUCED AND A VIRUS-INDUCED LEUKEMIA IN ISOLOGOUS MICE INOCULATED WITH A LEUKEMIA VIRUS

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4774906

Sachs, L

Inoculation with Moloney leukemia virus (MLV), but not with polyoma virus (PV) or culture fluid from an x-rayinduced leukemia (RL), inhibited the growth of isologous transplants of an MLV-induced leukemia in C57BL/6 mice. No inhibitory effect of inoculation with MLV or RL fluid was found on the growth of isologous transplants of an x-ray-induced leukemia. Inoculation with MLV also did not inhibit the growth of isologous transplants of a PV-induced tumor. The results indicate that the MLV-induced leukemia has acquired a new cellular antigen; that this antigen is different from the new cellular antigen in PV- induced mouse tumors; and that the MLV-induced antigen does not seem to be present in the x-ray-induced leukemia. The new antigen was maintained in the MLV- induced leukemia for at least 64 transplant generations. It is stressed that such experiments with leukemia provide a simple method for a comparison of new antigens induced by the known leukemia viruses and new antigens in leukemias induced by physical and chemical agents. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-17-000082
• OSTI ID: 4774906
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 29; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIGENS
BIOLOGY AND MEDICINE
IMMUNITY
LEUKEMIA
MICE
POLYOMA VIRUS
TRANSPLANTS
TUMORS
VIRUSES
X RADIATION