Immunologically Privileged Sites in Studies of Polyoma Tumor Antigens

Journal Article · Wed May 01 04:00:00 EDT 1963 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-113-28303· OSTI ID:4674334

Habel, K.; Belcher, J. H.

Two polyoma tumors in mice were found to have a 1,000-fold increased transplantability if the IC or IT routes of inoculation are used instead of SC. When polyoma virus-immune mice were challenged by the IC or IT routes, the degree of demonstrable resistance was 10⁵ and 10⁴ minimal transplantable numbers of cells as compared to 10¹ by the SC route. Mice immunized IC or SC with a single dose of x irradiated tumor cells and later challenged IC showed protection in the IC but not the SC immunized group. The ability of in vitro polyoma transformed tissue culture cells to produce tumors on inoculntion of isologous adult mice was most markedly enhanced by whole-body x irradiation, but best results were obtained if IC inoculation was made into irradiated animals.

• Research Organization: National Inst. of Allergy and Infectious Diseases, Bethesda, Md.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-031915
• OSTI ID: 4674334
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 1 Vol. 113; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AGE
ANTIGENS
BODY
CANCER
CULTURES
CYTOLOGY
HEART
IMMUNITY
MICE
POLYOMA VIRUS
QUANTITY RATIO
RADIATION DOSES
SKIN
TISSUES
TRANSPORT
VARIATIONS
VIRUSES
X RADIATION