SYNTHESIS OF SPECIFICALLY IODINE-131-AND CARBON-14-LABELED THYROXINE
Journal Article
·
· Journal of Organic Chemistry (U.S.)
OSTI ID:4771638
A simple synthesis of various forms of radioactive L-thyroxine, carrying the label (I/sup 131/ or C/sup 14/) either in the phenolic ring or in the nonphenolic ring and in the side chain, is described, It is based on the coupling of 4hydroxy-3,5-diiodophenylpyruvic acid and 3,5-diiodotyrosine. Labeled 4- hydroxy-3,5-diiodophenylpyruvic acid was prepared by iodination of p- hydroxybenzaidehyde foilowed by condensation with acetylglycine and hydrolysis of the azlactone formed, or by enzymic oxidative deamination of diiodotyrosine. (auth)
- Research Organization:
- National Inst. of Arthritis and Metabolic Diseases, Bethsda, Md.
- NSA Number:
- NSA-17-001540
- OSTI ID:
- 4771638
- Journal Information:
- Journal of Organic Chemistry (U.S.), Journal Name: Journal of Organic Chemistry (U.S.) Vol. Vol: 27; ISSN JOCEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Simple synthesis of (3,5-/sup 125/I)diiodo-L-thyronine and of (3,5-/sup 125/I)L-thyroxine of high specific activity
SYNTHESIS OF RING-LABELED l-THYROXINE-C$sup 1$$sup 4$
THE EFFECT OF pH AND MOLAL RATIO IN THE PREPARATION OF RADIOIODINE-LABELED THYROXINE AND 3,5,3'-TRI-IODOTHYRONINE
Journal Article
·
Sat Oct 01 00:00:00 EDT 1977
· Endocrinology; (United States)
·
OSTI ID:5335082
SYNTHESIS OF RING-LABELED l-THYROXINE-C$sup 1$$sup 4$
Journal Article
·
Thu Oct 31 23:00:00 EST 1963
· Journal of Medicinal Chemistry (U.S.)
·
OSTI ID:4077215
THE EFFECT OF pH AND MOLAL RATIO IN THE PREPARATION OF RADIOIODINE-LABELED THYROXINE AND 3,5,3'-TRI-IODOTHYRONINE
Journal Article
·
Thu Aug 01 00:00:00 EDT 1963
· Intern. J. Appl. Radiation Isotopes
·
OSTI ID:4637802
Related Subjects
ACETYL RADICALS
ALDEHYDES
AMINO ACIDS
BENZOIC ACID
CARBON 14
CHEMICAL REACTIONS
CHEMISTRY
DIIODOTYROSINE
ENZYMES
GLYCINE
HYDROLYSIS
IODINATION
IODINE 131
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC IODINE COMPOUNDS
OXIDATION
PHENOLS
PHENYL RADICALS
PREPARATION
PYRUVIC ACID
RADIOCHEMISTRY
THYROXINE
TYROSINE
ALDEHYDES
AMINO ACIDS
BENZOIC ACID
CARBON 14
CHEMICAL REACTIONS
CHEMISTRY
DIIODOTYROSINE
ENZYMES
GLYCINE
HYDROLYSIS
IODINATION
IODINE 131
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC IODINE COMPOUNDS
OXIDATION
PHENOLS
PHENYL RADICALS
PREPARATION
PYRUVIC ACID
RADIOCHEMISTRY
THYROXINE
TYROSINE