The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13
Journal Article
·
· Genomics
OSTI ID:476891
- St. Jude Children`s Research Hospital, Memphis, TN (United States); and others
Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the {beta}-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12-p13.13, using fluorescence in situ hybridization. 12 refs., 2 figs.
- OSTI ID:
- 476891
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 39; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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