THE EFFECT OF X IRRADIATION AND CYSTEAMINE ON THE BARBITURATE SLEEPING TIME IN RATS
Whole-body x irradiation with 600 and 800 r prolongs barbiturate sleeping time in the rat. In the head-irradiated animals (with the same doses) no prolongation of barbiturate sleeping time was observed. Irradintion of the animal with the head shielded produced the same effect as irradiation of the whole body. Cysteamine depressed or even blocked the prolonging action of x irradiation on barbiturate sleeping time. This action of cysteamine was evident 24 hr after irradiation and was still present 30 days after irradiation. The prolonging effect of x irradiation was significant as early as 24 hr after exposure but was more pronounced 14, 21, and 30 days after irradiation. This suggests that even the primary event which takes place immediately after absorption of radiation energy produces a change in reactivity to barbiturates. The results obtained with headirradiated animals indicate that the reactivity of the central nervous system to barbiturates is not significantly changed. Therefore, x irradiation may produce some change in the detoxication process of barbiturates in the liver. Or, some biologically active substance might be released which contributes to the prolongation of the effect of barbiturates. Possibly 5-hydroxytryptamine liberated by x irradiation from intestine might contribute to the prolongation of the barbiturate hypnosis. (H.H.D.)
- Research Organization:
- Inst. for Nuclear Sciences "Boris Kidric," Belgrade
- NSA Number:
- NSA-17-005788
- OSTI ID:
- 4768348
- Journal Information:
- Arch. Intern. Pharmacodyn., Vol. Vol: 138; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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