The Effect of Methysergide and X-irradiation on the Barbiturate Sleeping-time in Rats
Methysergide (1-methyl-D-lysergic acid butanolamide bimaleate), a highly potent and specific 5-hydroxytryptamine antagonist, if injected after irradiation, significantly depresses the proionging effect of x irradiation on the barbiturate sleeping-time in rats. Lysergic acid diethylamide did not show tius type of activity. 5-Hydroxytryptamine, when injected before irradiation, did not depress the typical response of the irradiated animals to barbiturates. When used after irradiation, 5-hydroxytryptamine caused a further prolongation of the barbiturate sleeping-time. Cysteamine, when injected before irradiation, depressed or blocked the prolonging effect of x irradiation on the barbiturate sleeping-time. When injected after irradiation, cysteamine was found to cause a further prolongation of the barbiturate sleeping-time. The mechanisms of action of methysergide, 5-hydroxytryptamine, and cysteamine are briefly discussed. (auth)
- Research Organization:
- Boris Kidrich Inst. for Nuclear Sciences, Belgrade; and Medical Faculty, Belgrade
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-010418
- OSTI ID:
- 4712135
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 6 Vol. 5; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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