The Effect of Methysergide and X-irradiation on the Barbiturate Sleeping-time in Rats

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006214551201· OSTI ID:4712135

Varagić, V.; Stepanović, S.; Hajduković, S.

Methysergide (1-methyl-D-lysergic acid butanolamide bimaleate), a highly potent and specific 5-hydroxytryptamine antagonist, if injected after irradiation, significantly depresses the proionging effect of x irradiation on the barbiturate sleeping-time in rats. Lysergic acid diethylamide did not show tius type of activity. 5-Hydroxytryptamine, when injected before irradiation, did not depress the typical response of the irradiated animals to barbiturates. When used after irradiation, 5-hydroxytryptamine caused a further prolongation of the barbiturate sleeping-time. Cysteamine, when injected before irradiation, depressed or blocked the prolonging effect of x irradiation on the barbiturate sleeping-time. When injected after irradiation, cysteamine was found to cause a further prolongation of the barbiturate sleeping-time. The mechanisms of action of methysergide, 5-hydroxytryptamine, and cysteamine are briefly discussed. (auth)

• Research Organization: Boris Kidrich Inst. for Nuclear Sciences, Belgrade; and Medical Faculty, Belgrade
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010418
• OSTI ID: 4712135
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 6 Vol. 5; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BARBITURIC ACID
BEHAVIOR
BIOLOGY AND MEDICINE
BRAIN
CYSTEAMINE
DRUGS
HETEROCYCLICS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATION PROTECTION
RATS
X RADIATION