ELECTRON MICROSCOPIC STUDIES ON THE CORPUS LUTEUM OF TOTALLY IRRADIATED RATS
Adult female nonpregnant rats were submitted to 50- or 300-rad Co irradiation, and 2 hr later the fine structure of their corpora lutea was examined. After 50 rad the following changes were noted, especially in the so- called dark cells: swelling of the nucleus, thickening of and irregularities in nuclear membrane with loss of its doublelamellar structure, clumping of chromatin, and swelling of mitochondria. Subendothelial and intercellular spaces are enlanged, presumably on account of the edema produced by irradiation. After the 300-rad dose these changes are more pronounced and in addition the nuclei show contraction, mitochondrial structure is distorted, endoplasmic reticulum is fragmented, and cavities are present in the lipid secretory granules. The results show that even relatively low radiation doses induce significant changes in corpus luteum cells as early as 2 hr after irradiation. (H.H.D.)
- Research Organization:
- Universita, Florence
- NSA Number:
- NSA-17-001334
- OSTI ID:
- 4766458
- Journal Information:
- Sperimentale (Italy), Journal Name: Sperimentale (Italy) Vol. Vol: 112; ISSN SPERA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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