THE ROLE OF THE LOCAL AND DISTANT EFFECTS OF TOTAL BODY X-IRRADIATION IN INJURING MICE OVARIES
Journal Article
·
· Tr. Inst. Genet., Akad. Nauk SSSR
OSTI ID:4762358
Sexually mature line A, female mice, weighing 19 to 28 g each were divided into 4 groups. One group was subjected to whole-body irradiation with a dose of 100 r, which was not lethal but caused irreversible sterilization. The 2nd group was subjected to local irradiation of the ovaries (irradiated area---30 x 18 mm). In the 3rd group only the heads were irradiated, while the 4th group was not irradiated at all. The estrual cycle of the animals was investigated by daily examining vaginal smears for the first 3 months and during the 6th and 9th months after irradiation. In addition, 3 and 5 months after irradiation all the mice were checked for fertility by placing them in the same cage with nonirradiated males for 2 weeks and recording the size of each liter and the number of stillborn progeny. The results showed that the injury caused by whole- body x irradiation of mice with a non-lethal sterilizing dose (100 r) is due to local damage of the ovaries. (P.C.H.)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-012169
- OSTI ID:
- 4762358
- Journal Information:
- Tr. Inst. Genet., Akad. Nauk SSSR, Journal Name: Tr. Inst. Genet., Akad. Nauk SSSR Vol. Vol: No. 26
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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