THE RADIOSENSITIVITY OF THE PROCESSES OF DNA-SYNTHESIS IN MOUSE SPLEEN
Journal Article
·
· Intern. J. Radiation Biol.
The effect of different doses of x rays on DNA-synthesis in mouse-spleen lymphocytes during the synthetic period was studied in vivo and in vitro. DNA- synthesis was measured by the incorporation of H/sup 3/ or C/sup 14/-thymidine. The data confirmed that the radiosensitivity is markedly greater in vivo. The discrepancy was not readily remedied by fortification of the incubation medium by energy-producing substances, and the increased depression did not seem to be due to the release of DNA-metabolites or an inhibitor of DNA-synthesis by the intact spleen. A triphasic response for lymphocytes in vivo is postulated to explain the greater radiosensitivity. (auth)
- Research Organization:
- Churchill Hospital, Oxford
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-005830
- OSTI ID:
- 4754820
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 5
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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