Anomalies in Chromosomes of the Circulating Leukocytes in Man Following Large Doses of Radioactive Iodine

Journal Article · Sat Dec 01 04:00:00 EST 1962 · Journal of Clinical Endocrinology and Metabolism

DOI:https://doi.org/10.1210/jcem-22-12-1171· OSTI ID:4754721

MACINTYRE, M. NEIL; DOBYNS, BROWN M.

Observations made on a single patient who had thyroidal carcinoma with functioning metastases and who was given a therapeutic dose of 167 mC of I¹³¹ are reported. At frequent intervals during the first 24 hr, and less frequently thereafter for 14 days, the concentration of radioactivity and the leukocyte and differential counts were determined. Simultaneously, cultures of leukocytes were made as a source of chromosomal preparations. Spreads of chromosomes from many individual cells of each culture were counted and analyzed. Numerous anomalies of structure and number were found. In most instances the abnormality was a chromosomal number less than the normal of 46, but in some instances the counts exceeded the normal. An occasional 4n nucleus was seen. Chromosomal breakage and dicentric forms occurred. Finally, the maximal frequency of anomalies occurred during the period of 3 to 12 hr after I¹³¹ administration and corresponded to the maximal concentration of I¹³¹ in the blood.

• Research Organization: Cleveland Metropolitan General Hospital
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-005836
• OSTI ID: 4754721
• Journal Information: Journal of Clinical Endocrinology and Metabolism, Journal Name: Journal of Clinical Endocrinology and Metabolism Journal Issue: 12 Vol. 22; ISSN 0021-972X
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CANCER
CHROMOSOMES
IODINE 131
LEUCOCYTES
MAN
MEDICINE
METASTASES
RADIATION INJURIES
RADIOTHERAPY
THYROID