Carcinogenic Effect of Prolonged Exposure to Grenz Ray
Journal Article
·
· Journal of Investigative Dermatology
Mice were exposed to grenz ray in low dosage (50 to 100 r/day) over a prolonged period (up to 9 months), giving a total dosage of 20000 or 30000 r. Following irradiation they were kept under observation for a period of 1 year. No conclusive differences in longevity of irradiated and control groups were noted. The antimalarial drugs, Triquin and chloroquine, which initially appeared to offer some protection to the skin of the ears did not prevent the development of squamous cell carcinomas. Squamous cell carcinomas were produced in 22% of mice receiving a total dose of 30000 r of grenz ray but none occurred in those receiving only 20000 r. Additional changes consisting of dorsal hair loss and telangiectasia plus slight thickening of ear margins were noted in all irradiated animals but the changes were less severe in the groups receiving only 20000 r. It was found that grenz rays appear to be similar to x rays in yielding a postirradiation carcinogenic effect. Most of the tumors formed were on the back, face, or neck; only 1 formed on an ear. All other tumors that developed were of breast origin of a type that apparently occurs spontaneously in this strain of mice. It was concluded that the squamous cell carcinomas that developed are attributable to the grenz rays. (P.C.H.)
- Research Organization:
- Baylor Univ.,Houston, Tex.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-015823
- OSTI ID:
- 4748957
- Journal Information:
- Journal of Investigative Dermatology, Journal Name: Journal of Investigative Dermatology Journal Issue: 4 Vol. 37; ISSN 0022-202X
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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