A HISTOPATHOLOGIC STUDY IN MICE IMMUNIZED AGAINST TRICHINELLA SPIRALIS AND EXPOSED TO TOTAL-BODY X IRRADIATION

Journal Article · Sat Sep 01 04:00:00 EDT 1962 · American Journal of Tropical Medicine and Hygiene (U.S.)

OSTI ID:4748410

Larsh, Jr, J E; Race, G J; YArinsky, A

Immunized and nonimmunized mice were irradiated with 450 r and challenged with 200 T. spiralis larvae. The larvae used for the immunizing but not the challenging) injections had been sterilized by x irradiation (3500 r). Histopathologic changes in small intestine were studied at various intervals postchallenge. Nonirradiated, immunized mice showed a subacute inflammatory response similar to that in untreated mice at 7 days postchallenge. However, the irradiated, immunized mice showed a response that differed in type and degree. In those irradiated 12 days prior to chailenge (19 days prior to necropsy), there was a striking subacute response, which was similar, except in intensity, to that noted in the nonirradiated, immunized mice. Extensive lymphoid proliferation in the irradiated mice suggested recovery was underway. The findings were consistent with adult-worm counts for comparable groups in classifying the immune status. By both measurements, those irradiated 8 days prior to the challenge had no demonstrable acquired immunity, while those irradiated 12 days prior to challenge had immunity of an intermediate degree. On the basis of these and other observations an hypothesis is presented to explain the irradiation interference with previously established immunity. (P.C.H.)

• Research Organization: Univ. of North Carolina, Chapel Hill
• NSA Number: NSA-17-015654
• OSTI ID: 4748410
• Journal Information: American Journal of Tropical Medicine and Hygiene (U.S.), Journal Name: American Journal of Tropical Medicine and Hygiene (U.S.) Vol. Vol: 1; ISSN AJTHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANIMALS
BIOLOGY AND MEDICINE
BODY
CYTOLOGY
DISEASES
EMBRYOS
IMMUNITY
INTESTINE
LARVAE
LYMPHOCYTES
MICE
PARASITES
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RECOVERY
STERILIZATION
TRICHINELLA
VARIATIONS
X RADIATION