ON THE NUTRITIVE VALUE OF THE MAJOR NUTRIENTS OF IRRADIATED FOODS AND APPRAISAL OF THE TOXICITY OF IRRADIATED FOODS. Progress Report No. 21, September 1, 1961-March 1, 1962
Vitamin K was found to be an essential nutrient for newborn pigs fed a synthetic milk diet. Fourteen out of 15 animals developed symptoms that included highly significant increases in prothrombin time, hypersensitivity, anemia, anorexia, and weakness. The animals responded to oral or intramuscular administration of vitamin K in 2 to 4 hr. Preliminary studies on the incorporation of C/sup 14/ -labeled amino acids into rat liver protein and the synthesis of hepatic tryptophan-pyrrolase in the liver of normal and vitamin-K deficient rats indicate that vitamin K is apparently not involved in the synthesis of proteins. Macaca mulatta monkeys approximately one year old were fed a synthetic vitamin K-free diet for periods as long as 9 months with only slight prolongation of prothrombin time. With the addition of high levels of antibiotics in the diet the animals showed signs of a somewhat greater deficiency in vitamin K, anemia, anorexia, weakness, hypersensitivity, hemorrhage, and a prolonged prothrombin time. The monkeys responded clinically and biochemically to the administration of vitamin K at dosages as low as 0.06 mu g/kg body weight. No signs of dangerous side effects were observed in monkeys that received oxytetracycline and neomycin for periods as long as 7 and 9 weeks respectively, and at dosages as great as 100 and 400 mg/kg body weight per day respectively. Applications are discussed of these findings in determinations of the nutritional value of gamma irradiated beef, which was shown to be low in vitamin-K content. (C.H.)
- Research Organization:
- Illinois. Univ., Urbana Page(s): 30
- DOE Contract Number:
- DA-49-007-MD-544
- NSA Number:
- NSA-16-033344
- OSTI ID:
- 4748147
- Report Number(s):
- NP-12093
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- United States
- Language:
- English
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