STUDIES ON PLASMA LACTIC DEHYDROGENASE IN MICE WITH MYELOID LEUKEMIA. I. RELATION OF ENZYME LEVEL TO COURSE OF DISEASE

Journal Article · Thu Feb 28 23:00:00 EST 1963 · Cancer Research (U.S.)

OSTI ID:4748095

Nishio, K; Jacobson, K B; Jenkins, V K; Upton, A C

The plasma lactic dehydrogenase (LDH) activity was increased in RF mice with primary and transplanted radiation induced myeloid leukemia. The degree of elevation in mice with transplanted leukemia varied irregularly with the time after transplantation and with the transplant generation, the mean of all values being about 14 times normal. The extent of LDH increase in any transplant generation was correlated with the severity of leukemic infiltration of the liver and other organs. This correlation indicates that LDH mirrors the severity of the leukemic process. Whole-body x-radiation in the absence of transplanted leukemia, also caused a transient elevation of plasma LDH. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-17-017661
• OSTI ID: 4748095
• Journal Information: Cancer Research (U.S.), Journal Name: Cancer Research (U.S.) Vol. Vol: 23; ISSN CNREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD PLASMA
DEHYDROGENASES
ENZYMES
LACTIC ACID
LEUKEMIA
LIVER
MICE
ORGANIC ACIDS
QUANTITY RATIO
RADIATION EFFECTS
TRANSPLANTS
X RADIATION