INFLUENCE OF IONIZING RADIATION ON GLUTAMINASE ACTIVITY IN MOUSE BRAIN AND LIVER

Journal Article · Sat Dec 22 04:00:00 EST 1962 · Nature

DOI:https://doi.org/10.1038/1961223a0· OSTI ID:4740002

Ababei, L; Schiau, S; Capiln, S; Ghizari, E; Stoenescu, R; Stefanescu, P

A significant inhibition of glutaminase activity was demonstrated in the brain and liver of mice after whole-body exposure for 58 min to 500 r x radiation. The inhibition increased progressively for 48 hr after irradiation. Similar resuits were reported previously for carboxypeptidose activity. It was concluded the decrease of the activity of these mitochondrial enzymes may be explained as a consequence of changes in the synthesis of new proteins, and therefore also of enzymal proteins. Since both enzymes have active SH groupings, it is postulated they may be inhibited by the direct action of x rays on these groupings. (C.H.)

• Research Organization: Inst. of Normal and Pathological Physiology, Academy of Sciences, Rumanian SSR
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-007862
• OSTI ID: 4740002
• Journal Information: Nature, Journal Name: Nature Vol. Vol: 196
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
BODY
BRAIN
ENZYMES
LIVER
MICE
RADIATION DOSES
RADIATION EFFECTS
X RADIATION