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IRRADIATION AND ANTICOAGULANT THERAPY TO PREVENT PULMONARY METASTASES OF THE V2 CARCINOMA IN RABBITS

Journal Article · · Radiology (U.S.)
OSTI ID:4739178
Irradiated cancer cells disappeared from the circulating blood in rabbits more quickly than nonirradiated cancer cells. Irradiation of cancer cells with 1,000 r did not alter significantly the growth potential of these cells. Single doses of heparin or fibrinolysin reduced the production of pulmonary metastases by both irradiated and nonirradiated cells. The decrease was greatest with the irradiated cells. Heparin and fibrinolysin administered daily for six days after the intravenous inoculation of irradiated cancer cells markedly reduced the occurrence of puliaonary metastases. (auth)
Research Organization:
Sloan-Kettering Inst. for Cancer Research, New York; and Cornell Univ., New York
NSA Number:
NSA-17-017690
OSTI ID:
4739178
Journal Information:
Radiology (U.S.), Journal Name: Radiology (U.S.) Vol. Vol: 80; ISSN RADLA
Country of Publication:
Country unknown/Code not available
Language:
English

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