THE RELATION OF RADIATION DOSE TO RADIATION DAMAGE IN THE MANDIBLE OF WEANLING RABBITS
Journal Article
·
· Archives of Oral Biology (England)
OSTI ID:4738688
Weanling rabbits injected with a single dose of Sr/sup 90/Cl/sub 2/ in amounts from 100 to 1000 mu C/kg were killed at intervals up to 180 days. Autoradiographic and dosimetric studies were performed on the mandibles of one side and histological studies on the other. The pattern of Sr/sup 90/ retention in the teeth differed in rabbits given 600 mu C/kg or more from those given 100 mu C/kg or less, owing to retardation of tooth eruption and growth in the former group. Dose rates were measured along two lines in the mid-vertical plane of the mandible and variations in dose rate with time after injection for rabbits of higher and lower injected doses were recorded. Variation of accumulated dose with time after injection was also calculated. Severe and early changes in tooth growth occurred aftei the higher injected doses, teeth becoming narrower, retarded, or arrested in growth. Alveolar bone ceased to grow, but 2 to 3 months after injection, pleomorphic osteoblastic proliferations arose on the surface of sockets and by 6 months resorption of tooth and bone accompanied growths regarded as osteosarcomas. No tumors arose from dental tissues. The accumulated dose at the tumor sites was 7500 to 9000 rad, and several tibial osteosarcomas were noted, occurring at doses of 10000 to 15000 rad. The sites of osteogenic sarcoma in the mandible and in the long bones were similar. (H.H.D.)
- Research Organization:
- Guy's Hospital, London
- NSA Number:
- NSA-17-017804
- OSTI ID:
- 4738688
- Journal Information:
- Archives of Oral Biology (England), Journal Name: Archives of Oral Biology (England) Vol. Vol: 3; ISSN AOBIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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