PRINCIPLES GOVERNING THE DEVELOPMENT OF OSTEOGENIC SARCOMA INDUCED BY RADIOACTIVE ISOTOPES
Administration of Sr/sup 89/, Sr/sup 90/, Sr/sup 89/ + Sr/sup 90/, Y/sup 90/, Y/sup 91/, Ba/sup 140/, 47/, as well as solutions of fission products of uranium in doses of 0.005 to 3.0 mu c/g (rats) and 0.2 to 1.5 mu c/g (rabbits), leads to the development of osteosarcoma in animals surviving for more than 200 days. The time of survival of animals with bone tumors and the frequency of metastasis formation are inversely Proportional to the dose. Sex has no influence upon the frequency of development of malignant bone tumors. The size and capacity of the dose received by the bone tissue is of decisive importance for the formation of osteosarcoma. Malignant bone tumors develop in rats and in rabbits after the same period of time. Multiple growth of osteosarcoma occurs more frequently in rabbits than in rats and the formation of metastases is more frequent and more abundant in rabbits. (auth)
- Research Organization:
- Academy of Medical Sciences, USSR
- NSA Number:
- NSA-14-021224
- OSTI ID:
- 4174943
- Journal Information:
- Problems of Oncol. (U.S.S.R.e (English Translation), Journal Name: Problems of Oncol. (U.S.S.R.e (English Translation) Vol. Vol: 5, No. 8
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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