INDIRECT DISTURBANCES IN CARDIOVASCULAR ORGANOGENESIS CAUSED BY X-RAY DESTRUCTION OF REGIONS SITUATED BEHIND THE HEART RUDIMENT

Journal Article · Fri Sep 01 04:00:00 EDT 1961 · J. Embryol. Exptl. Morphol.

OSTI ID:4737190

Le Douarin, N

X-ray destruction of wide transverse strips situated behind the heart rudiment in chick embryos at 9- to 22somite stages resulted in cardiovascular malformations. Embryos surviving at least to the 7th day of incubation were studied by injecting the arterial system with India ink and cutting the heart transversely at different levels. Malformations were more frequent and serious the closer the anterior margin of the irradiated strip approached the heart and the more extensive the destroyed region. Arterial anomalies affected mainly the brachiocephalic trunks, and, less frequently, the arch of the aorta. Disturbances of morphogenetic movements, especially of the rotation of the arterial bulbus. occurred in the development of the heart itself. The partitioning of the heart was affected in places: the pulmo-aortic septum of the bulb failed to form or remained incomplete, and the interventricular foramen did not close. The heart, therefore, in some respects maintained the organization it had at an earlier stage. In contrast, the interartenial and interventricular septa developed normally. (H.H.D.)

• Research Organization: College de France, Paris
• NSA Number: NSA-17-017850
• OSTI ID: 4737190
• Journal Information: J. Embryol. Exptl. Morphol., Journal Name: J. Embryol. Exptl. Morphol. Vol. Vol: 9
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BIRDS
BLOOD VESSELS
CHICKENS
DYES
EMBRYOS
HEART
INDIA INK
MALFORMATIONS
RADIATION INJURIES
TISSUES
X RADIATION