INDUCTION OF HOMOGRAFT TOLERANCE IN ADULT MICE BY SUBLETHAL X-IRRADIATION AND INJECTION OF HOMOLOGOUS SPLEEN CELLS
Journal Article
·
· Transplantation (Baltimore)
Homograft tolerance was induced in adult DBA/2 mice by sublethal x irradiation and an injection of a suspension of adult BALB/c spleen cells. The optimal conditions for thls procedure were determined by varying the dose of x irradiation (200 to 400 r), the time of splenic injection (1 to 72 hours after irradiation), the time of skin grafting (1 to 17 days after irradiation), and the dose of spleen cells (0.01 to 1.0, expressed as a fraction of one spleen). The first 3 factors were found to be of maximal importance. The mortality attributable to the ertire procedure was 2%. The procedure failed to induce tolerance across an H-2 barrier. The possible use of this system as a model for studying tolerance induction and maintenance was emphasized.
- Research Organization:
- Stanford Univ., Palo Alto, Calif.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-015760
- OSTI ID:
- 4727745
- Journal Information:
- Transplantation (Baltimore), Journal Name: Transplantation (Baltimore) Journal Issue: 1 Vol. 1; ISSN 0041-1337
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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