THE CLINICAL AND PATHOLOGICAL EFFECTS OF RENAL IRRADIATION

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Progr. Radiation Therapy

OSTI ID:4725465

Luxton, R W

From a study of 54 patients over a 13-yr period the following radiotherapy-induced syndromes are described: acute and chronic radiation nephritis, benign hypertension, late malignant hypertension, and proteinuria. Of 20 patients who were followed, 8 had malignant hypertension, of whom 6 died within 3 to 12 months. The remaining 2 recovered spontaneously from the malignant phase of hypertension, but 1 of the 2 died 6 years later wtth chronic renal failure. In patients who survived acute radiation nephritis, improvement usually began within 6 months after the first symptom. Of the patients who have not died from the effects of renal irradiation, 1 died of recurrent ovarian malignancy. The remaining 9 are alive and active at an average interval of 10 years after radiotherapy, although all show evidence of chronic nephritis. The main histological findings of acute radiation nephritis comprise thickening of the renal capsule, widespread glomerular damage (hyaline obliteration of capillary loops, necrosis of fibrinoid or of hemorrhagic type with proliferation of capsular epithelium and early capsular fibrosis), extensive tubular degeneration and atrophy, diffuse intertubular fibrosis, and fibrinoid necrosis of arterioles and interlobular arteries. The glomerulus is the primarily affected portion of the kidney and tubular atrophy is secondary. Under modern conditions, radiation nephritis is largely a preventable disorder. (TCO)

• Research Organization: Christie Hospital and Holt Radium Inst., Manchester, Eng.
• NSA Number: NSA-17-019871
• OSTI ID: 4725465
• Journal Information: Progr. Radiation Therapy, Journal Name: Progr. Radiation Therapy Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD VESSELS
CANCER
CYTOLOGY
GONADS
HEMORRHAGE
KIDNEYS
MAN
MEDICINE
NEPHRITIS
RADIATION INJURIES
RADIOTHERAPY