RADIATION NEPHRITIS: A LONG-TERM STUDY OF 54 PATIENTS

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Lancet (England)

DOI:https://doi.org/10.1016/S0140-6736(61)92590-9· OSTI ID:4721125

Luxton, R W

S>Radiation nephritis may result when the kidneys are included in therapeutic fields of deep x rays. In 54 patients observed over 13 yr, initial clinical presentations were acute radiation nephritis (20 cases), primary chronic radiation nephritis (10), benign hypertension (8), late malignant hyfentension (5), and proteinuria (13). In acute radiation nephritis the immediate prognosis was related to the occurrence of malignant hypertension from which spontaneous recovery followed in 2 patients. After recovery from the acute phase, chronic nephritis always remained. Chronic radiation nephritis may develop insidiousiy (primary chronic radiation nephritis) or it may follow acute radiation nephritis (secondary chronic radiation nephritis). The ultimate prognosis may be better in the secondary type. Of 6 patients with benign hypentension syndrome, 2 died of congestive heart failure and 1 of malignant hypentension. Proteinuria alone, after renal irradiation, may denote a latent form of nephritis. Of the 54 patients, 15 (28%) developed malignant hypentension sooner or later. Thus the study supports the concept obtained from animal experiments that x irradiation of the kidneys has 2 distinct and independent biological effects: hypertension and interstitial fibrosis. (H.H.D.)

• Research Organization: Christie Hospital, Manchester, Eng.
• NSA Number: NSA-17-010440
• OSTI ID: 4721125
• Journal Information: Lancet (England), Journal Name: Lancet (England) Vol. Vol: 2; ISSN LANCA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DISEASES
KIDNEYS
MAN
NEPHRITIS
PROTEINS
QUANTITY RATIO
RADIATION INJURIES
RADIOTHERAPY
RECOVERY
URINE
X RADIATION