INORGANIC CONSTITUENTS OF THE DIET AND RADIOSENSITIVITY: LETHAL RESPONSE TO X RAYS AND TO NITROGEN MUSTARD OF RATS FED DIETS SUPPLEMENTED WITH MANGANESE
Experiments were conducted in rats fed diets enriched with 3 to 33 mg Mn per day (as MnCl/sub 2/) above the basal diet content of 15 g Mn per day. In general, Mn supplementation decreased the growth of rats, the decrease exceeding 50% at the highest Mn level (33 mg/day). Whole-body irradiation of the rats was carried out with 624 r on the 75th day of the dietary regimen. Rats on the basal diet showed a 30-day mortality rate of 72%. This was in contrast to rats on 2.78, 11.12, 16.68, and 22.24 mg/day Mn supplements, which showed respective 30- day mortality rates of effect of dietary Mn was demonstrable. In another group of rats on similar diets, nitrogen mustard (1.2 mg/kg body wt) was injected intraperitoneally and the 15-day mortality rate was determined. This was significantly lower (38%) in rats fed 16.68 mg Mn per day than in controls on the basal diet (64% mortality). No explanation could be offered for the partial protective action of Mn against nitrogen mustard. (H.H.D.)
- Research Organization:
- Istituto Superiore di Sanita, Rome
- NSA Number:
- NSA-17-019872
- OSTI ID:
- 4725463
- Journal Information:
- Rend. 1st. Super. Sanita, Journal Name: Rend. 1st. Super. Sanita Vol. Vol: 24
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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