CHANGES IN CLEARANCE OF Fe$sup 59$ FROM PLASMA IN THE INITIAL STAGE OF BONE MARROW INJURY AFTER SUBLETHAL TOTAL-BODY IRRADIATION (in German)
Bone marrow function was assessed by the disappearance of injected Fe/ sup 59/ from the plasma of rats given 800 to 800 r Co/sup 60/ irradiation ( approximates LD/sub 50/ at 30 days) or 1000 r (LD/sub 100/). The isotope studies were supplemented with histological examination of the marrow. After a single whole-body LD/sub 50/30/ dose the marrow showed edema and massive hemorrhage, accompanied by disruption of capillary sinusoids. This was followed by an occlusion of the marrow vascular system that persisted up to about 10 days after irradiation. Marrow insufficiency was also evident from the greatly prolonged half time of plasma Fe/sup 59/ clearance of 350 min, compared with the normal value of 90 min. This is a reflection of the marked destruction by radiation of marrow parenchymal cells. The Fe/sup 59/ clearance curve shows an early inflection point at about 25 to 30 min after injection (indicating an initial haif time of 15 to 20 min), then declines very slowly thereafter. (H.H.D.)
- Research Organization:
- Universitat Heidelberg
- NSA Number:
- NSA-17-010413
- OSTI ID:
- 4721732
- Journal Information:
- Folia Haematol. (Frankfurt), Vol. Vol: 6; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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