EXPLORATION OF ERYTHROPOIETIC FUNCTION BY MEANS OF RADIOACTIVE IRON IN THE RAT IRRADIATED AND TREATED BY BATYL OR SELACHYL ALCOHOL (in French)
Journal Article
·
· Rev. Franc. Etudes Clin. Biol.
OSTI ID:4134098
Erythropoietic activity was followed in rats irradiated and subsequently treated with batyl or selachyl alchol. By means of radioiron (Fe/sup 59/), the relation between erythropoietic activity and x-ray dose, and the activity as a function of time after a given dose, were studied. Male rats (Institut du Cancer strain L) were exposed to 250-kv x rays at 42 r/min to doses of 100, 250, or 400 r (the 30-day LD/sub 50/ for this strain is 450 r). Batyl or selachyl alcohol was injected subcutaneously at a dose of 2 mg/day in 0.16 ml of peanut oil (controls received oil alone). Injection of Fe/sup 59/ solution (as 0.33 mu C FeCl/sub 3/) was made subcutaneously in all groups of rats on the 3rd, 6th, 9th, and 12th days after irradiation. Erythropoietic activity of irradiated rats decreased, as shown by Fe/sup 59/ incorporation in circulating red cells, with increasing x-ray doses. These alcohols did not conclusively diminish the depressant effect of radiation on erythropoiesis. In all cases, maximum depressiom of red cell formation occurred on the third postirradiation day, after which it increased in both alcohol-treated and untreated animals. The slight differences found were not statistically significant. These results therefore do not confirm the radioprotective effects of these alcohols, at least with regard to erythropoiesis in the rat, although Edlund and others have demonstrated that they prolong life and enhance leukocyte repletion in irradiated mice. (BBB)
- Research Organization:
- Institut du Cancer, Louvain, Belg.
- NSA Number:
- NSA-18-005146
- OSTI ID:
- 4134098
- Journal Information:
- Rev. Franc. Etudes Clin. Biol., Journal Name: Rev. Franc. Etudes Clin. Biol. Vol. Vol: 7
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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