RADIOIODINE IN DIAGNOSIS AND THERAPY OF HYPERTHYROIDISM CAUSED BY HYPERFUNCTIONING THYROID ADENOMA
Of 48 patients having clinical hyperthyroidism caused by proved hyperfunctioning adenoma, as determined by I scintigrams 25 had normal 24-hr thyroidal I/sup 131/ uptake values. The I/sup 131/ scintigrams of the 46 patients revealed that only 1 hyperfunctioning adenoma of the thyroid was present in each goiter. No significant I/sup 131/ uptake was observed in the normal thyroidal tissue outside of the adenoma. The results of therapy with an initial large dose I/sup 131/, delivering from 15 to 30 mC (average 21.4 mC) to the adenoma, showed that 76% of the patients were euthyroid within 2 months, and all 21 patients within 4 months, after treatment. In contrast, when a moderate initial dose of I/sup 131/ delivering 6 to 14 mC (average 10.1 mC) to the adenoma was given to 38 patients with toxic nodular goiter (presumed hyperfunctioning adenoma) with hyperthyroidism, only 16% were euthyroid within 2 months and 53% within 4 months. In each of the 21 patients the hyperfunctioning adenoma decreased in size but did not disappear after I/sup 131/ treatment. No significant clinical exacerbation of hyperthyroidism occurred. No significant early or late radiation effect has yet been observed in any of the patients treated with I/sup 131/, and in none of the treated patients has hypothyroidism developed. (TCO)
- Research Organization:
- Cleveland Clinic Foundation
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021407
- OSTI ID:
- 4719121
- Journal Information:
- Arch. Internal Med., Journal Name: Arch. Internal Med. Vol. Vol: 110
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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