MATURATION OF LIVER FUNCTION IN THE CHICK EMBRYO

Technical Report · Fri Dec 14 04:00:00 EST 1962

OSTI ID:4718807

Brauer, R W; Julian, L M; Krebs, J S

A detailed study of the process of maturation of liver function in the developing chick embryo reveals at least three different time courses describing various aspects of the phenomena. Conjugation and concentrating or storing ability are well developed by the 9th day of incubation; maximal BSP transfer capacity matures by the 14th day; and clearance of BSP and ability to secrete selectively submaximal doses of BSP may not have reached maturity by the 18th day of incubation. Finaily, while conjugating and concentrating abilities of the liver for BSP are clearly present on the 8th and 9th days, the ability to secrete BSP into bile does not appear until the 11th day of incubation. Analysis of the data suggests that two broad aspects of functional maturation must be considered. These include functional maturation at the level of individual cells, including organelle development, membrane differentiation, and appearance of specific enzymes and functional maturation at the organ level, involving both juxtaposition of cell populations and tissue elements, and uniformity of attainment of functional maturity. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-17-017653
• OSTI ID: 4718807
• Report Number(s): USNRDL-TR-603
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BIRDS
CHEMICAL REACTIONS
CHICKENS
EMBRYOS
ENZYMES
LIVER
MEMBRANES
METABOLISM
ORGANIC BROMINE COMPOUNDS
REAGENTS
TESTING