Effect of Oxidative Phosphorylation Inhibitors on Synthesis of Liver Mitochondria Phospholipids.

Journal Article · Fri Feb 01 04:00:00 EST 1963 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-112-28025· OSTI ID:4717230

Youngs, J. N.; Cornatzer, W. E.

The effect of single doses of arsenate, bilirubin, dinitrophenol, and oligomycin on synthesis of mitochondria phospholipids of liver of rats was studied. A statistically significant decrease occurred in synthesis of phosphatidyl inositol, sphingomyelin, lecithin, phosphatidyl serine, and phosphatidyl ethanoiamine of liver mitochondria following administration of dinitrophenol. Administration of arsenate, oligomycin, and bilirubin inhibited statistically the incorporation of the isotope into all the phospholipid fractions of liver mitochondria except sphingomyelin and phosphatidyl inositol. However, oligomycin inhibited incorporation of the isotope into the sphingomyelin fraction and arsenate inhibited the phosphatidyl inositol fraction. (auth)

• Research Organization: Univ. of North Dakota, Grand Forks
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-023002
• OSTI ID: 4717230
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 2 Vol. 112; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIBIOTICS
ARSENIC COMPOUNDS
BILIRUBIN
BIOLOGY AND MEDICINE
CORROSION PROTECTION
CYTOLOGY
ENZYMES
INHIBITION
ISOTOPES
LIPIDS
LIVER
METABOLISM
MITOCHONDRIA
ORGANIC PHOSPHORUS COMPOUNDS
OXIDATION
OXIDATIVE PHOSPHORYLATION
PHENOLS
PHOSPHOLIPIDS
PHOSPHORUS
PIGMENTS
QUANTITY RATIO
RATS
REDUCTION
STATISTICS
STERILIZATION
SUGARS