The Effect of Radiation on the Production of Mucin in Salivary Glands and the Female Genital Tract of Rodents

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Annals of the New York Academy of Sciences

DOI:https://doi.org/10.1111/j.1749-6632.1963.tb16670.x· OSTI ID:4717128

Glücksmann, A.

Pelvic exposure of rats and mice to doses of 300 to 400 r resulted in increased mucin secretion and suppression of keratinization. Estrogen prevented or modified keratinization suppression by radiation, depending on the timing of radiation and of estrogen administration. Similar results were obtained with vaginal cells in tissue cultures. Vitamin A also inhibited the keratinization of vaginal epithelium. The salivary glands in rats showed long-term changes in type and quantity of secretion after irradiation with doses of 850 r/day for 4 days. Radiation damaged the reproductive capacity of acinar cells and induced a compensatory secretory activity in cells of the sublingual ducts and hypertrophy of the secretory tubules of the submandibular. (C.H.)

• Research Organization: Strangeways Research Lab., Cambridge, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-023103
• OSTI ID: 4717128
• Journal Information: Annals of the New York Academy of Sciences, Journal Name: Annals of the New York Academy of Sciences Journal Issue: 2 Vol. 106; ISSN 0077-8923
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
ESTROGENS
GLANDS
HORMONES
MICE
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RATS
RODENTS
SALIVARY GLANDS
SEX
STEROIDS
TISSUES
VARIATIONS
VITAMIN A
VITAMINS