COMPARISON OF EFFECTS OF DEUTERIUM OXIDE AND X-RAY IRRADIATION ON MULTIPLICATION OF POLIOVIRUS
An attenuated strain of poliomyelitis virus (CHAT) will not grow in monkey kidney cells at 40 un. Concent 85% C. When deuterium oxide (25 to 40%) is present in the medium, replication of CHAT virus will take place at 40 un. Concent 85% C. Since both deuterium oxide treatment and irradiation with x rays yield giant cells, the 2 treatments have been compared for their ability to support the growth of CHAT poliovirus at 40 un. Concent 85% C. At several levels of x irradiation, monkey kidney cells will not support the growth of CHAT virus at 40 un. Concent 85% C. When D/sub 2/O is added to he medium of the x- irradiated cells at 40 un. Concent 85% C, replication of CHAT virus is observed. The effect is not due to cell size or number. (auth)
- Research Organization:
- Wistar Inst. of Anatomy and Biology, Philadelphia
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-023134
- OSTI ID:
- 4717088
- Journal Information:
- Proc. Soc. Exptl. Biol. Med., Vol. Vol: 112; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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