Ionizing radiation, and other DNA damaging agents, can improve the integration of exogenous DNA into human and mammalian cells
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
OSTI ID:471546
- Univ. of Pennsylvania, Philadelphia, PA (United States)
Ionizing radiation has many effects within target cells; one of the most important is the ability of radiation to induce DNA damage. While it has proved difficult to isolate ionizing radiation-induced DNA repair enzymes in higher eukaryotes, radiation clearly induces a wide variety of specific gene transcripts. The control of genetic recombination is also not well understood in higher eukaryotes. We hypothesized that either the physical changes (e.g., nicks and double strand breaks induced by radiation), one or more of the radiation-induced proteins, or both might enhance the ability of DNA to integrate into mammalian chromosomes. The purpose of this project was to use radiation, and certain other DNA damaging agents, to improve the delivery of gene therapy.
- OSTI ID:
- 471546
- Report Number(s):
- CONF-9510337--
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: Suppl.1 Vol. 32; ISSN IOBPD3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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