The Ablation of Normal Thyroid Tissue with Iodine 131
It was found that the minimum radiation dose of I131 for complete ablation of the thyroid gland is probably between 30000 and 40000 rads, but for practical purposes it is safer to assume that it may be as high as 50000 rads. A radiation dose of 50000 rads requires an initial concentration of about 1 mC of I131/g of thyroid tissue, but, if the rate of turnover of I131 in the thyroid is very rapid, a higher initial concentration may be necessary, and this must be taken into account when calculating the amount of I131 that has to be given to the patient. Failure to ablate the thyroid completely in patients with angina is not a serious matter provided the patient becomes sufficiently hypothyroid after the treatment. It is advisable, on the other hand, to ensure complete destruction of all remaining thyroid tissue in patients who have had one lobe containing a thyroid carcinoma removed. Doses of 80000 to 100000 rads, which produce massive destruction of thyroid tissue, may be indicated in these circumstances.
- Research Organization:
- Hammersmith Hospital; and Postgraduate Medical School, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021496
- OSTI ID:
- 4715006
- Journal Information:
- British Journal of Radiology, Journal Name: British Journal of Radiology Journal Issue: 425 Vol. 36; ISSN 0007-1285
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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