IRRADIATION AND TISSUE IMMUNITY. II. RESPONSE TO INJECTION OF STAPHYLOCOCCI IN X IRRADIATED SKIN AREAS OF RABBITS
Twenty-four hrs after 1000-r x irradiation of a small area of the skin of rabbits, they were injected with a suspension of staphylococci subcutaneously in the irradiated area and in a nonirradiated control area. Localized lesions were most marked in nonirradiated areas and in some animals no visible lesions were noted in irradiated areas. The mild inflammatory lesions in irradiated areas corroborate the point of view, that irradiation is anti-inflammatory. The reason for mild lesions must be the reduced localization of staphylococci in irradiated areas and their escape from those areas. It is suggested that the antilocalizing property of irradiation is probably the basis for the antiinflammatory action. When the concentration of organisms injected in the irradiated area was high (10 billion), septicemia and death of the rabbits occurred, presumably as a result of the antilocalizing property of irradiation, which permitted the escape of the organisms from the injected area. In animals injected in irradiated areas with either 0.5 or 5 billion organisms, no septicemia was observed, presumably because of the high natural immunity of rabbits to staphylococci. (TCO)
- Research Organization:
- Univ. of Michigan, Ann Arbor
- NSA Number:
- NSA-17-021520
- OSTI ID:
- 4715002
- Journal Information:
- J. Infect. Diseases, Vol. Vol: 110; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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