Thyroid Carcinoma in Man after Exposure to Ionizing Radiation: A Summary of the Findings in Hiroshima and Nagasaki
Journal Article
·
· New England Journal of Medicine
A survey was made of thyroid carcinoma incidence detected during a 3-yr period in the populations of Hiroshima and Nagasaki to determine whether a relation exists between previous exposure to ionizing radiation and the subsequent development of thyroid carcinoma. All cases were found during routine medical examinations of matched groups of exposed and nonexposed subjects. The data presented for 20000 subjects strongly suggest that there is a highly significant correlation between proximal exposure to the radiation of atomic weapons and the eventual development of thyroid carcinoma. Of 355 patients found to have enlarged thyroid glands in Hiroshima and Nagasaki, 21 patients with histologically confirmed thyroid carcinoma were seen. If patients are grouped according to distance from the hypocenter, a significant increase in the prevalence of thyroid carcinoma is seen among those more heavily irradiated, with 14 of 21 cases occurring within 1399 m. The distribution of the Hiroshima cases is highly significant, and analysis of the data for both cities combined shows a prevalence of thyroid carcinoma among the more heavily exposed that is also highly significant.
- Research Organization:
- Atomic Bomb Casualty Commission, Hiroshima; and Nagasaki
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021540
- OSTI ID:
- 4714965
- Journal Information:
- New England Journal of Medicine, Journal Name: New England Journal of Medicine Journal Issue: 8 Vol. 268; ISSN 0028-4793
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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