A CHROMOSOME STUDY OF RADIATION SENSITIZATION BY 5-BROMODEOXYURIDINE
Journal Article
·
· Exptl. Cell Res.
Mammalian cells grown in vitro were utilized to study radiosensitization following 5-bromodesoxyuridine (BUDR) treatment. Maximum radiation sensitivity of BUDR treated and untreated cell populations, measured in terms of chromosome damage, was found in metaphase cells sampled at the first mitosis following irradiation. A nonrandom distribution of chromatid breaks was found in chromosome No. 1 of Chinese hamster cells treated with BUDR prior to irradiation. A cell line, derived from strain L of the mouse, resistant to BUDR did not show maximum radiosensitivity. (auth)
- Research Organization:
- Univ. of Texas, Houston
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-027093
- OSTI ID:
- 4698305
- Journal Information:
- Exptl. Cell Res., Journal Name: Exptl. Cell Res. Vol. Vol: 30
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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