THE INFLUENCE OF METABOLIC FACTORS ON RADIOSENSITIVITY

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Laval Medical (Canada)

OSTI ID:4697175

Ghys, R

In rats injected intramuscularly with 25 mg/100 g testosterone propionate 8 hr before irradiation, the hormone had a radiosensitizing effect in males but not in females, on the basis of increased mortality rate. This was observed with radiation from fast (2-Mev) neutrons and the BETA emitter P/sup 32/, and with the radiomimetic drug Myleran. Diarrhea and anemia were accentuated by testosterone in the male rats, whereas it ameliorated the effects in female rats. The anabolic steroid methandrosthenolone (Danabol) also sensitized male rats to gamma radiation from Co/sup 60/, and the effect was not modified by hypophysectomy or castration. Estradiol had a greater radiosensitizing effect than testosterone in male rats. Danabol, although increasing radiation injury to bone marrow cells, tended to attenuate the digestive symptoms, which were attributed to the improved electrolyte balance produced by this steroid in irradiated rats. Exposure of rats to coid (1 deg C), following irradiation, considerably accelerated their metabolic rate and aggravated the effects of radiation. However, rats acclimated to cold are more resistant to radiation, whether maintained in the cold or at room temperature following irradiation. Such cold-adapted rats were shown to have lower body weight, higher liver weight, and higher plasma protein levels than control rats. (H.H D.)

• Research Organization: Laval Univ., Quebec
• NSA Number: NSA-17-027209
• OSTI ID: 4697175
• Journal Information: Laval Medical (Canada), Journal Name: Laval Medical (Canada) Vol. Vol: 34; ISSN LAMEA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ANEMIA
BETA DECAY
BIOLOGY AND MEDICINE
BLOOD PLASMA
BODY
BONE MARROW
CANADA
COBALT 60
CONFERENCE
DIFFUSION
DRUGS
ELECTROLYTES
FAST NEUTRONS
GAMMA RADIATION
GLANDS
GONADS
HORMONES
HYPOPHYSIS
INTESTINE
LIVER
METABOLISM
MYLERAN
PHOSPHORUS 32
PROTEINS
QUANTITY RATIO
RADIATION INJURIES
RADIOSENSITIVITY
RATS
SEX
STEROIDS
SURGERY
TEMPERATURE
TESTOSTERONE
VARIATIONS
WEIGHT